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Lecturer(s)
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Richter Igor, doc. MUDr. Ph.D.
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Course content
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Lectures: 1) Introduction, definition of radiotherapy and its position in the complex treatment of malignant tumors, cancer care system in the Czech Republic 2) Cell cycle and effect of ionizing radiation on the cell; possibilities of cell damage repair 3) Effect of ionizing radiation on tissues; principles of early and late effects after irradiation 4) Cell survival curves; therapeutic ratio and possibilities of its influence; radiosensitizers, possibilities of radioprotection, importance of oxygen in radiotherapy 5) Adverse effects of radiotherapy on the possibilities of its influence 6) Batch, time, fractionation; fractionation regimes in radiotherapy, advantages and disadvantages, clinical use 7) Radiotherapy planning: principles, history, 2D planning, 3D conformal planning, inverse planning, IMRT technique, rotational techniques; collimation systems 8) Target volumes in radiotherapy, critical organs, isodose plan, DVH 9) Imaging methods for radiotherapy planning and their fusion 10) Verification imaging systems in radiotherapy (development, kilovoltage and megavoltage imaging) 11) Regular checking and setting of volume parameters (in accordance with valid protocol) 12) Beam calibration using special ionization chambers, phantoms and other instruments, dosimetric comparative measurement, audit, dose determination accuracy, basics of clinical dosimetry, types of dosimeters and their use in radiotherapy Exercises: 1) The role and principles of radiotherapy and its position in complex cancer treatment 2) Mechanism of radiation effects on cells and tissues, therapeutic ratio and possibilities of its influence 3) Procedures in planning radiotherapy, fixation aids in radiotherapy 4) Requirements for beam parameters, beam calibration, dosimetric comparative measurement, dose determination accuracy 5) Quality control of photon and electron beam 6) Setting beam parameters, simulators and imaging methods for planning treatment procedures
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Learning activities and teaching methods
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Lecture, Practicum
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Learning outcomes
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The course Radiotherapy 1 acquaints students with the definition of radiotherapy as a therapeutic component of cancer. It deals in more detail with the description of the effect of ionizing radiation on cells and tissues, with the possibilities of modifying this effect. It deals with undesirable effects of radiotherapy and its treatment. It also acquaints students with procedures of radiotherapy planning and quality control.
Students obtain knowledge in given course in accordance with requirements and course programme.
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Prerequisites
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Preconditions are frased in the annotation of the course and in the curriculum of the studying programme.
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Assessment methods and criteria
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Written exam
Credit: - 80% participation in exercises, - preparing a presentation on a given topic, - written test.
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Recommended literature
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BINAROVÁ, Andrea. Radioterapie. Ostrava: Ostravská univerzita v Ostravě, 2010. ISBN 978-80-7368-701-4.
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DOROTÍK, Jan. Radioterapeutické přístroje. Ostrava: Vysoká škola báňská - Technická univerzita, 2007. ISBN 978-80-248-1376-9.
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FELTL, David a Jakub CVEK. Klinická radiobiologie. Havlíčkův Brod: Tobiáš, 2008. ISBN 978-80-7311-103-8.
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HYNKOVÁ, Ludmila a Pavel ŠLAMPA. Radiační onkologie - učební texty. Brno: Masarykův onkologický ústav, 2009. ISBN 978-80-86793-13-9.
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HYNKOVÁ, Ludmila a Pavel ŠLAMPA. Základy radiační onkologie. Brno: Masarykova univerzita, 2012. ISBN 978-80-210-6061-6.
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JURGA, Ľudovít. Klinická a radiačná onkológia. Martin: Osveta, 2011. ISBN 978-80-8063-302-8.
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ŠLAMPA, Pavel a Jiří PETERA. Radiační onkologie. Praha: Galén, 2007. ISBN 978-80-7262-469-0.
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