Course: Biomaterials for medical applications

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Course title Biomaterials for medical applications
Course code KCH/BMA
Organizational form of instruction Lecture + Lesson
Level of course Bachelor
Year of study not specified
Semester Summer
Number of ECTS credits 6
Language of instruction Czech
Status of course Compulsory, Optional
Form of instruction Face-to-face
Work placements Course does not contain work placement
Recommended optional programme components None
Lecturer(s)
  • Kuželová Košťáková Eva, doc. Ing. Ph.D.
Course content
Lectures: <ol> <li> Essential requirements for biomaterials for medical applications, separation of materials into fibrous and non-fibrous, advantages and disadvantages, uses, etc. </li> <li> Fiber biomaterials - biodegradable microfibers - used polymer materials, types of production technologies, properties, applications, advantages, problems, etc. </li> <li> Fiber materials - principles of DC and AC electrospinning technology. </li> <li> Fiber materials - electrospinning - modifications (fiber orientation, layer patterning, 3D objects creation.) </li> <li> Fiber materials - combination of materials - emulsion spinning, multijet electrospinning, foam spinning, nanofiber yarns, composite yarns, etc. </li> <li> Fiber Materials - Drawing - uniqueness of the process of creating individual fibers, flashspinning - an interesting technology for creating bulky scaffolds. </li> <li> Fiber Materials - Centrifugal Spinning - Basics of a Competitive Electric Spinning Process. </li> <li> Non-fibrous materials - Electrospraying. </li> <li> Non-fibrous materials - Foams - mechanical foaming, gas foaming, solvent casting, leaching. </li> <li> Non-fibrous materials - 3D printing - various variants and other principles of particle materials formation, eg solvent evaporation from emulsions. </li> <li> Postprocess modification, surface modification of polymer biomaterials. </li> <li> Testing of basic materials (polymers, polymeric liquids) for their suitability for individual production technologies (surface tension, viscosity, electrical conductivity), explanation of individual characteristics in relation to a particular production technology). </li> <li> Basic introduction of testing possibilities of manufactured materials, both fibrous and non-fibrous (optical microscopy, SEM, melting point, crystallinity). </li> <li> Examples of specific materials used, their production, their characteristics and their behavior in the process of use. </li> </ol> Exercises: Introduction of individual technologies including own production of biomaterials. Each exercise will produce material that students know exactly how they made and what the basic characteristics are. These materials can also be used for work in related subjects. <ol> <li> Electrostatic spinning from a needle - different molecular weights (layer), orientation of fibers on a rotating collector - evaluation on SEM. </li> <li> Electrospinning needle-free - various concentrations (electrospinning x electrospraying, combinations), layer patterning - evaluation on SEM. </li> <li> AC electric spinning - spinning and access diversity and in the form of fibers (layer formation, nanofiber yarn formation, composite yarn formation). </li> <li> Hydrogel formation, degree of swelling, etc. </li> <li> Drawing and centrifugal spinning and basic evaluation at SEM. </li> <li> Drug delivery - preparation of absorbable polymer microspheres and SEM evaluation. </li> <li> Gelatin foams - foaming, PCL foams - solvent casting, leaching. </li> </ol>

Learning activities and teaching methods
Project teaching, Laboratory work, Problematic methods (research and exploration), Lecture
  • Preparation for laboratory testing; outcome analysis - 14 hours per semester
  • Preparation for exam - 14 hours per semester
  • Class attendance - 56 hours per semester
Learning outcomes
Within this course, technology of production of materials for tissue engineering, wound covers and selected carriers for drug delivery systems will be lectured and practiced. The course is a follow-up to the knowledge and skills acquired in the course Introduction to Bioengineering. Students will learn the basic principles of materials creation for medical applications, especially in the field of tissue engineering, wound covers and drug delivery systems. Selected technologies of biomaterial production will be tested in exercises.
Theoretical knowledge and practical skills in the field.
Prerequisites
knowledge of secondary school biology

Assessment methods and criteria
Combined examination, Written assignment

Attendance at seminars, written and oral exam.
Recommended literature
  • LANZA R. P. LANGER R. S. VACANTI J. Principles of tissue engineering.. Fourth edition. Amsterdam: Academic Press, an imprint of Elsevier, 2014. ISBN 978-0123983589.
  • MA P. X. Biomaterials and regenerative medicine.. Cambridge, UK: Cambridge University Press, 2014. ISBN 978-1107012097.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester