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Lecturer(s)
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Tománková Hana, Ing. M.Sc.
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Rysová Miroslava, Ing. Ph.D.
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Course content
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Lectures: 1. Introduction to the topic - Material safety and legislation. Basic toxicology, industrial and environmental toxicology. 2. Substantial entrance into an organism and mechanisms of penetration of toxic substances. Harmful effects on the organism. 3. Toxokinetics. 4. Toxicity evaluation. Toxicological methods, tests and biotests. Legislation and manipulation with poisons and other pollutants, controlled substances and their precursors. 5. Basic characteristic of hazardous and toxicological properties of elements, inorganic and organic compounds. 6. Environmental toxicology. Exposure and permissible limits. Hygienic aspects. 7. Industrial toxicology. Main groups of industrial intoxications. Overview of hazardous occupations and exposure risks. Protective and preventive precautions in industrial production. 8. Toxicology of poisons, pollutants, environmental disaster, terrorism. 9. Characterization of nanomaterials. Nanotoxicology. 10. Toxicity of nanomaterials: from production to nanomedicine. Nanomaterials in food, water, cosmetics and other products. 11. Advantages of nanotechnology for the environment. Ecotoxicology of nanomaterials. 12. Potential of nanomaterials in medicine. Organ-specific toxicity of nanomaterials, immunotoxicity and genotoxicity. 13. Handling nanomaterials in a workplace. 14. Legislation in CZ, EU, USA.
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Learning activities and teaching methods
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Monological explanation (lecture, presentation,briefing), Self-study (text study, reading, problematic tasks, practical tasks, experiments, research, written assignments)
- Class attendance
- 28 hours per semester
- Preparation for exam
- 20 hours per semester
- Presentation preparation (report)
- 12 hours per semester
- Semestral paper
- 30 hours per semester
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Learning outcomes
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The aim of this subject is primarily to clarify a connection of (nano)materials with living systems. The main focus is on safety aspects from the developing process, production, application to disposal of (nano)materials. Students will be provided with information on basic terms in toxicology, industrial and environmental toxicology. Furthermore, students will be introduced to the mechanisms of the effect of pollutants and toxic substances at different levels. Factors determining toxic action will be explained. The course will be completed introducing current legislation and work safety.
Students will acquire basic knowledge of the industrial and environmental toxicology. They will have an overview of currently evolving legislation on safety manipulation with (nano)materials. Emphasis is given to the nanotoxicology because of a significant nanotechnology expansion in last years and related an increasing requirement for the evaluation of potential risks resulting from a contact of nanomaterials with living organism.
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Prerequisites
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Unspecified
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Assessment methods and criteria
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Written exam
Credit requirement is an attendance at lectures, at least 70% or an individual written essay. The exam is written, in exceptional cases after mutual agreement the exam might be oral.
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Recommended literature
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Filipová Z. Rizika nanomateriálů. Univerzita Palackého v Olomouci, 2012.
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Churáček J., Jeník J. Analytická toxikologie. VŠCHT Pardubice, 1984.
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Luther W., Axel Zweck A. Safety Aspects of Engineered Nanomaterials. Pan Stanford, 2013.
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Matrka M., Rusek V. Průmyslová toxikologie: Úvod do obecné a speciální toxikologie. VŠCHT Pardubice, 1998.
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Prokeš J. Základy toxikologie. Obecná toxikologie a ekotoxikologie.. Praha, Karolinum - Galén, 2005.
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Tichý M. Toxikologie pro chemiky. Karolinum Praha, 2004.
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