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Lecturer(s)
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Kuželová Košťáková Eva, doc. Ing. Ph.D.
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Course content
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Lectures: 1. Introduction to tissue engineering - triad, history, imitation of nature. 2. Cells and extracellular matrices - organization of cells into higher ordered structures, cell-matrix interactions; In-vitro tissue development management, bioreactors - introduction to technologies. 3. Biomaterials in tissue engineering - interaction of cells with polymers and extracellular matrix effect. 4. Biodegradable polymers - selection criteria, biodegradability. 5. Technology of production of polymeric tissue carriers - fiber bonding, solvent casting, aprticular leaching, freeze drying, gas foaming etc. 6. Technology of production of polymeric tissue carriers - electrospinning and other technologies of production of fibrous tissue carriers. 7. Tissue carriers for cardiovascular system - criteria for tissue carrier formation, examples. 8. Tissue carriers for cornea - criteria for creation of tissue carriers, examples. 9. Tissue carriers for gastrointestinal system - gastrointestinal tract, liver - criteria for tissue carrier formation, examples. 10. Tissue carriers for musculoskeletal system - bones, cartilage, tendons and ligaments - criteria for formation of tissue carriers, examples. 11. Tissue carriers for the nervous system and dental applications - criteria for the formation of tissue carriers, examples. 12. Tissue carriers for skin - criteria for creation of tissue carriers, examples. 13. Testing of materials for tissue carriers - brief introduction to surface and volume physical and chemical characterization and biomechanics. 14. Regulatory issues in the development, testing and application of tissue carrier materials. Semestral work is a research work focused on a specific type of tissue and the possibility of manufacturing tissue carriers.
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Learning activities and teaching methods
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Project teaching, Problematic methods (research and exploration), Lecture
- Semestral paper
- 34 hours per semester
- Preparation for exam
- 14 hours per semester
- Class attendance
- 28 hours per semester
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Learning outcomes
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The topic of this course is the issue of production and testing of tissue carriers especially with biodegradable polymeric materials. The introduction introduces tissue engineering and its individual tools and procedures. Furthermore, attention is focused on typical basic materials for tissue engineering and their current processing and production technology according to the final application of tissue carriers of various types. Last but not least, there are briefly summarized methods of characterization or testing of manufactured tissue carriers and problems of their regulation under current conditions.
Theoretical knowledge and practical skills in the field.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Combined examination, Written assignment
Semestral work, combined exam.
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Recommended literature
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FISHER J. P. MIKOS A. G. BRONZINO J. D. PETERSON D. R. Tissue Engineering:Principles and Practices.. 1. vydání, CRC Press, 2017. ISBN 9781138077867.
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LANZA R. P. LANGER R. S. VACANTI J. Principles of tissue engineering.. Fourth edition. Amsterdam: Academic Press, an imprint of Elsevier, 2014. ISBN 978-0123983589.
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SALTZMAN, Mark W. Tissue Engineering. Oxford University Press, 2004. ISBN 9780195141306.
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