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Lecturer(s)
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Lukáš David, prof. RNDr. CSc.
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Havlíčková Kristýna, Ing. Ph.D.
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Course content
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Lectures: 1. Fundamentals of pharmacokinetics 2. Introduction to drug delivery systems (history, basic concepts). 3. Overview of drug delivery system mechanisms. 4. Classification of materials for controlled drug delivery, overview of polymers. 5. Diffusion-controlled systems - Random walk theory. 6. Diffusion equation - First and second Fick's law. 7. Solving the diffusion equation in Cartesian and cylindrical coordinates. 8. Mathematical models for drug release. 9. Diffusion in biological systems, polymers, and gels. 10. Examples of applications of drug delivery systems. Exercises: Laboratory assignments related to lectures
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Learning activities and teaching methods
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Project teaching, Laboratory work, Problematic methods (research and exploration), Lecture, Students' portfolio
- Home preparation for classes
- 10 hours per semester
- Preparation for exam
- 60 hours per semester
- Class attendance
- 56 hours per semester
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Learning outcomes
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Synthetic materials have unprecedented potential for the treatment of human diseases. The course is focused on properties and development of biomaterials in relation to polymer chemistry and polymer physics. The aim is a qualitative and quantitative description of the mechanisms and principles that govern the rate of transport and release of drugs, their reactions and their degradation. The aim of the course is to provide basic knowledge for the development of methods and biomaterials for drug delivery and release.
1. Theoretical knowledge - Understands the principles of pharmacokinetics and the basics of drug transport in biological systems. - Is familiar with the history and basic concepts of controlled drug delivery systems and their mechanisms. - Knows the types of materials and polymers used for drug carriers and their properties. 2. Mathematical and physical competencies - Can apply Fick's laws and other diffusion models to describe drug transport. - Can solve diffusion equations in various geometric coordinates and use mathematical models for drug release. - Understands the theory of random walks and its use in describing diffusion in polymers and gels. 3. Analytical and experimental skills - Ability to analyze the kinetics of drug release from various types of carriers. - Ability to evaluate the influence of material and physicochemical parameters on drug diffusion and transport. - Ability to critically assess experimental data and results from the literature. 4. Application skills - Ability to link theoretical knowledge with practical applications in a pharmaceutical and biomedical context. - Understanding of the principles of diffusion-controlled release and ability to interpret specific examples of applications. 5. Communication and interdisciplinary skills - Ability to formulate the results of their analysis and system proposals clearly in both written and oral form. - Familiarity with professional literature in pharmacy, materials engineering, and biomedicine.
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Prerequisites
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1. Basic knowledge of chemistry and biochemistry 2. Introduction to pharmacology or pharmacokinetics 3. Knowledge of physical chemistry and thermodynamics - Diffusion and transport phenomena in liquids and polymers - Basic principles of chemical equilibrium and kinetics 4. Mathematical and physical skills - Knowledge of derivatives and integrals - Solving simple differential equations - Basic knowledge of linear algebra and working with functions 5. Introduction to materials engineering or polymers (recommended) 6. English at a technical-scientific level (recommended)
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Assessment methods and criteria
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Combined examination
Examination: 100% attendance at laboratory exercises and completion of reports; combined form of examination (written test + oral examination)
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Recommended literature
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BRUSCHI, Marcos Luciano. Strategies to Modify the Drug Release from Pharmaceutical Systems. Cambridge. 2015.
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Hein, L. et al. Color Atlas of Pharmacology. New York. 2017.
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SALTZMAN W. M. Drug Delivery - Engineering Principles for Drug Therapy. Oxford University Press, 2001. ISBN 0195085892.
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SIEPMANN J. SIEGEL R. A. RATHBONE M. J. Fundamental and Applications of Controlled Release Drug Delivery. Springer, 2012. ISBN 978-1-4614-0881-9.
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