Course: Drug release systems

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Course title Drug release systems
Course code KCH/SUL
Organizational form of instruction Lecture + Lesson
Level of course Master
Year of study not specified
Semester Summer
Number of ECTS credits 6
Language of instruction Czech, English
Status of course Compulsory
Form of instruction Face-to-face
Work placements Course does not contain work placement
Recommended optional programme components None
Lecturer(s)
  • Mikeš Petr, Ing. Ph.D.
Course content
Lectures: 1. Introduction to drug release systems. 2. Overview of mechanisms of drug release systems. 3. Distribution of controlled release materials, overview of polymers. 4. Diffusion-controlled systems - Random walk. 5. First and second Fick's law. 6. Solution of diffusion equation in Cartesian and cylindrical coordinates. 7. Mathematical model - Higuchi approximation. 8. Porous systems - basics of percolation theory. 9. Diffusion in biological systems, polymers and gels. 10. Passage of drugs through biological barriers. 11. Hydrogels - release systems. 12. Degradable systems, mechanisms of degradation associated with drug release. 13. Basics of pharmacokinetics. 14. Examples of application of release systems. Exercises: The lectures will be practiced at seminars.

Learning activities and teaching methods
Project teaching, Problematic methods (research and exploration), Lecture
  • Home preparation for classes - 10 hours per semester
  • Preparation for exam - 60 hours per semester
  • Class attendance - 56 hours per semester
Learning outcomes
Synthetic materials have unprecedented potential for the treatment of human diseases. The course is focused on properties and development of biomaterials in relation to polymer chemistry and polymer physics. The aim is a qualitative and quantitative description of the mechanisms and principles that govern the rate of transport and release of drugs, their reactions and their degradation. The aim of the course is to provide basic knowledge for the development of methods and biomaterials for drug delivery and release.
Theoretical knowledge and practical skills in the field.
Prerequisites
unspecified

Assessment methods and criteria
Combined examination

Attendance at seminars, written and oral exam.
Recommended literature
  • SALTZMAN W. M. Drug Delivery - Engineering Principles for Drug Therapy. Oxford University Press, 2001. ISBN 0195085892.
  • SIEPMANN J. SIEGEL R. A. RATHBONE M. J. Fundamental and Applications of Controlled Release Drug Delivery. Springer, 2012. ISBN 978-1-4614-0881-9.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester