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Lecturer(s)
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Jirák Daniel, doc. Ing. Ph.D.
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Zeman Jan, Mgr. Ph.D.
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Course content
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Lectures: 1) Field definition; historical overview of methods and their development; most important methods for biomedicine, comparison of sensitivity methods (CT, MR, PET, gamma camera, SPECT, ultrasonography, IR and optical imaging) 2) Materials for cell and tissue transplantation 3) Radionuclide methods; physical principles, construction of equipment and equipment of the workplace 4) Gamma camera, SPECT 5) Positron emission tomography (PET) 6) Overview of contrast agents for individual imaging techniques; direct measurement of molecules and their structures for in vivo imaging 7) Optical methods, optical tomography, fluorescence and bioluminescence imaging in vivo 8) Magnetic resonance (MR) methods; resonance condition, chemical shift, interaction constant, 9) Introduction to MR imaging, construction of MR spectrometers and tomographs 10) MR imaging - T1 and T2 relaxation, MR image contrast 11) In vivo MR spectroscopy - single voxel MR spectroscopy, 12) Methods of spectroscopic imaging, methods of in vivo evaluation of MR spectra, nuclei used in in vivo MR spectroscopy, observable metabolites in spectra and their biochemical pathways 13) Cell marking for MR - procedures, visualization, multifunctional marks, applications 14) Theragnostics - basic principles and applications Exercises: 1) Comparison of methods sensitivity (CT, MR, PET, gamma camera, SPECT, ultrasonography, IR and optical imaging) 2) Optical methods, optical tomography, fluorescence and bioluminescence imaging in vivo 3) Analysis of bioluminescence images 4) Materials for cell and tissue transplantation 5) Radionuclide methods 6) Gamma camera, SPECT 7) Positron Emission Tomography (PET) 8) Overview of contrast agents for individual imaging techniques; direct measurement of molecules and their structures for in vivo imaging 9) Magnetic Resonance Imaging (MR) 10) Analysis of MR images, volumetry 11) MR imaging - T1 and T2 relaxation, MR image contrast, relaxometry 12) In vivo MR spectroscopy - single voxel MR spectroscopy, 13) Methods of spectroscopic imaging, methods of in vivo evaluation of MR spectra, nuclei used in in vivo MR spectroscopy, observable metabolites in spectra and their biochemical pathways 14) Cellular labeling for MR
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Learning activities and teaching methods
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Dialogue metods(conversation,discussion,brainstorming), Demonstration of student skills
- Presentation preparation (report)
- 12 hours per semester
- Class attendance
- 48 hours per semester
- Preparation for exam
- 10 hours per semester
- Home preparation for classes
- 20 hours per semester
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Learning outcomes
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The course will focus on progressive imaging methods, which find application in molecular and cellular imaging and teragnostics. It is based on theoretical knowledge acquired in the course Imaging Methods and Systems 1.
Students obtain knowledge in given course in accordance with requirements and course programme.
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Prerequisites
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Preconditions are frased in the annotation of the course and in the curriculum of the studying programme.
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Assessment methods and criteria
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Combined examination, Practical demonstration of acquired skills
Exam: - 80% participation in exercises, - credit test, - oral exam.
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Recommended literature
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BAXA, Jan a Jiří FERDA. Multidetektorová výpočetní tomografie srdce. Praha: Galén, 2012. ISBN 978-80-7262-880-3.
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FERDA, Jiří a kol. Základy zobrazovacích metod. Praha: Galén, 2015. ISBN 978-80-749-2164-3.
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FERDA, Jiří, Hynek MÍRKA a Jan BAXA. Multidetektorová výpočetní tomografie: technika vyšetření. Praha: Galén, 2009. ISBN 978-80-7262-608-3.
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HRAZDIRA, Ivo. Biofyzikální základy ultrasonografie: jak pracovat s ultrazvukovým diagnostickým přístrojem: praktická příručka s teoretickým úvodem pro stáž připravenou v rámci projektu: "Prohloubení odborné spolupráce. Olomouc: Univerzita Palackého v Olomouci, 2011. ISBN 978-80-244-2895-6.
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CHOLT, Milan. Sonografie velkých krčních cév: repetitorium ultrazvukové cévní diagnostiky a atlas nálezů. Praha: Grada, 2009. ISBN 978-80-247-2664-9.
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KESSEL, David et al. Interventional radiology: a survival guide. Edinburgh: Churchill Libingstone/Elsevier, 2011. ISBN 978-07-02033-896.
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KORANDA, Pavel. Nukleární medicína. Olomouc: Univerzita Palackého v Olomouci, 2014. ISBN 978-80-244-4031-6.
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MAREŠ, Jan. Detekce a včasná diagnostika poruch s aplikací na zpracování snímků počítačové tomografie: Detection and early diagnosis of diseases with application to computed tomography image analysis. Praha: České vysoké učení technické, 2014. ISBN 978-80-01-05567-0.
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SEIDL, Zdeněk. Radiologie pro studium i praxi. Praha: Grada, 2012. ISBN 978-80-247-4108-6.
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VOMÁČKA, Jaroslav. Zobrazovací metody pro radiologické asistenty. Olomouc: Univerzita Palackého v Olomouci, 2015. ISBN 978-80-244-4508-3.
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