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Vyučující
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Havelka Ondřej, Ing. Ph.D.
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Obsah předmětu
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1 Thinking back about the functionalization concept and how to get profit from it. Introduction. Review about the concept of functionalization. Methods of functionalization. 2 Cont. Review about the classes of functionalization: Thiol/Aminothiol, bio-functionalization, asymmetric groups, polymers in functionalization. 3 The physics behind stable colloids. The role of stability towards applications: DLVO theory, the reason to use surfactants as functionalization agents, and how to stabilize nanomaterials without the use of surfactants 4 Cont. Zeta potential, one way to measure the hydrodynamic stability of nanomaterials. Dynamic Light Scattering (DLS) and the measurement of hydrodynamic particle size. The role of velocity while measuring the size of a nanoparticle and how to tell if a nanoparticle is functionalized using DLS 5 PLAL, a unique technique for functionalization. Introduction to Pulsed Laser Ablation in Liquids (PLAL) a one-step synthesis and functionalization technique developed by a Czech-German research team. The twelve principles of green chemistry and why it is crucial to consider clean alternatives. Laser radiation; a tool to dissociate macro-metric systems and build nano-metric systems. Relationship between pulsed laser radiation and the electronic relaxation time 6 Cont. PLAL driven in media with functionalization agents. Step-by-step synthesis of nanoparticles and how the functionalization elements interact with the recently created particles. The use of PLAL for different solid materials. The importance of solutes during the synthesis process and when the solutes act as functionalization agents. The importance of solvents in the synthesis process and their role in the crystallinity of materials. 7 Reporting results about functionalization in real scientific journals. Discussion about specific techniques used nowadays to study the functionalization degree of nanomaterials. Introduction to high-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDS) and how to use the technique to recognize a correct functionalization. Review of DLS technique, how to use it to recognize a correct functionalization and the intimate relationship of nanomaterial velocity and their degree of functionalization. Introduction to ultraviolet-visible spectroscopy (UV-Vis), how to use the technique to recognize a correct functionalization, the sigmoidal curve, and how to calculate the exact number of molecules needed to functionalize a finite number of nanoparticles. 8 Cont. Introduction to Fourier transform-infrared spectroscopy (FT-IR), Raman Spectroscopy, nuclear magnetic resonance spectroscopy (NMR), X-ray Photoelectron Spectroscopy (XPS), inductive coupled plasma-mass spectroscopy (ICP-MS) and their importance in the functionalization of nanomaterials field. 9 Cont. Guidelines of an actual scientific journal and how to prepare HR-TEM, EDS, EDS mapping, DLS UV-Vis, FT-IR, Raman, NMR, XPS, and ICP-MS graphs that exhibit the functionalization degree of a wide range of nanomaterials. 10 Functionalization in real cases. In Situ Bioconjugation: Single Step Approach to Tailored Nanoparticle-Bioconjugates by Ultrashort Pulsed Laser Ablation. The use of TEM, DLS, UV-Vis, and XPS to understand why biomolecules can functionalize laser-synthesized nanoparticles. 11 Cont. Gold Nanoparticle-Enabled Blood Test for Early Stage Cancer Detection and Risk Assessment. Gold nanoparticles, their exploitation as bio-sensors, and why it is crucial to functionalize them with antibodies. The role of plasmonic nanoparticles functionalized with biomolecules to sense antigens. 12 Cont. Protein corona. The role of human immunoglobulin G to detect tumor-specific antigens. 13 Cont. A general overview of functionalization applied on polymers, textiles, ceramics, and metals. 14 Cont. A general overview of functionalization in photovoltaics, optoelectronics, drugs and medicinal approaches, catalysis, and sorption.
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Studijní aktivity a metody výuky
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Monologický výklad (přednáška, prezentace, vysvětlování), Samostatná práce studentů (studium textů, literatury, problémové úkoly,výzkum, pisemná práce), Prezentace a obhajoba písemné práce
- Příprava prezentace (referátu v cizím jazyce)
- 24 hodin za semestr
- Příprava na zkoušku
- 50 hodin za semestr
- Domácí příprava na výuku
- 10 hodin za semestr
- Účast na výuce
- 56 hodin za semestr
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Výstupy z učení
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The course provides an in-depth perspective of the phenomena behind functionalization, an introduction to photon and electron-based techniques that are currently used to assess the functionalization degree achieved in different materials, and finally, we are studying different real cases where functionalization of nanomaterials is exploited to get a useful application. The course is roughly divided into five sections: Thinking back about the functionalization concept and how to get profit from it, the physics behind stable colloids, PLAL; a unique technique for functionalization, reporting results about functionalization in real scientific journals, functionalization in practical cases. The course is designed to familiarize students with the concepts that are conventionally discussed in the research field from a physicochemical perspective and how the field is evolving. Each student is expected to understand most of the material presented in the course and in the assigned readings. Students completing this course should have an in-depth understanding of the functionalization phenomenon and how to present functionalization-related results in real scientific journals.
Students completing this course should have an in-depth understanding of the functionalization phenomenon and how to present functionalization-related results in real scientific journals.
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Předpoklady
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It is advised that the students interested in this course have already taken the course: KCH/UFN Introduction to functionalization of nanomaterials.
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Hodnoticí metody a kritéria
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Ústní zkouška, Esej, Ústní prezentace samostatné práce studenta
Assessment and Grading Final grades will be determined based on the following assignments. Overview The course assessment consists of two parts. To proceed to Part 2, the student must achieve at least 50% in Part 1. To pass the course, the student must achieve at least 50% in Part 2. Part 1 (minimum 50% required to proceed) Students must choose one of the following variants: Variant 1 Essay on a relevant topic: 40% Variant 2 Replication study on a relevant topic: 70% Part 2 (minimum 50% required to pass) If Variant 1 was selected in Part 1: Oral presentation on the topic: 30% AI-based oral exam on the topic: 30% If Variant 2 was selected in Part 1: AI-based oral exam on the topic: 30% Detailed Description of Assignments Part 1 Essay (Variant 1) The student will prepare an essay on a selected topic related to Functionalization of Nanomaterials. Language: English Content: A state-of-the-art overview of a currently relevant topic in nanomaterial functionalization Scope: Minimum 5 pages The essay should demonstrate the student's understanding and mastery of concepts covered in the course Formatting and submission guidelines must follow the AIP Publishing manuscript requirements, available at: https://aip.scitation.org/apm/authors/manuscript Submission deadline: no later than 5 days after the last lecture Replication Study (Variant 2) The student will replicate an experiment from state-of-the-art research in the field of Functionalization of Nanomaterials and prepare a short written report of the results. Language: English The report should clearly describe the original study, the replication methodology, obtained results, and a brief discussion of similarities or deviations from the original findings. Oral Presentation (Variant 1 only) The student will prepare an oral presentation based on the essay. Language: English Duration: 10 minutes Part 2 AI-Based Oral Examination Based on the topic selected in Part 1, the lecturer will conduct an AI-assisted oral examination assessing the student's understanding of the subject. The examination date will be arranged individually with the lecturer The exam will take place during the official examination period set by the university
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Doporučená literatura
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