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Lecturer(s)
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Jenčová Věra, doc. Ing. Ph.D.
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Havlíčková Kristýna, Ing. Ph.D.
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Course content
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Lectures: 1. Introduction to the course - Pharmacology (history, basic concepts; drugs, dosage forms - basic classification of drugs and their carriers; routes of drug administration; drug regulation, EU and FDA regulatory systems for medicinal products) 2. Pharmacokinetics and pharmacodynamics of drugs I 3. Pharmacokinetics and pharmacodynamics of drugs II 4. Drug delivery systems (DDS) - introduction to the topic, development, types of DDS 5. Controlled drug release - basic requirements, overview of drug release mechanisms 6. Fundamentals of pharmacokinetics - burst release, long-term release 7. Drug release and diffusion (First Fick's law) 8. Second Fick's law and the diffusion equation 9. Biomedical polymers for drug delivery systems 10. Hydrogels 11. Micro/nanoparticles 12. Electrospinning and electrospraying for the preparation of drug carriers 13. Degradable systems, degradation mechanisms associated with drug release 14. Examples of applications of drug delivery carriers I Seminars: Laboratory exercises are focused on practical exercises and verification of knowledge gained during lectures and study of recommended literature.
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Learning activities and teaching methods
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Self-study (text study, reading, problematic tasks, practical tasks, experiments, research, written assignments), Project teaching, Laboratory work, Problematic methods (research and exploration), Lecture, Students' portfolio
- Preparation for laboratory testing; outcome analysis
- 14 hours per semester
- Preparation for exam
- 80 hours per semester
- Class attendance
- 56 hours per semester
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Learning outcomes
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The course introduces students to the fundamentals of pharmacology (pharmacokinetics and pharmacodynamics), mechanisms of drug release, requirements for drug delivery carriers, their preparation and classification, as well as the approval process for these systems. Furthermore, students will become familiar with polymeric materials used for the preparation of drug carriers, including their characteristics and requirements. Practical knowledge will also be developed in the preparation and evaluation of materials for drug delivery systems, particularly for tissue engineering and regenerative medicine, including drug release mechanisms and the parameters influencing them.
1. Knowledge and understanding The student will be able to: - explain the basics of pharmacology, pharmacokinetics, and pharmacodynamics of drugs; - describe various forms of drugs and their carriers, methods of administration, and regulatory frameworks (EU and FDA); - distinguish between the types and principles of drug delivery systems (DDS) and their development; - explain the mechanisms of controlled drug release and the factors influencing release; - characterize polymeric materials, hydrogels, micro- and nanoparticles used for the preparation of drug carriers; - understand the principles of material degradation and their influence on drug release. 2. Practical skills (application of knowledge in practice) The student will be able to: - prepare and manipulate polymeric materials for DDS design and evaluate materials for drug carriers suitable for tissue engineering and regenerative medicine; - perform measurements and analysis of drug release, apply Fick's laws and other mathematical models of diffusion; - develop laboratory protocols and interpret experimental results. 3. Analytical and evaluation skills The student will be able to: - critically evaluate the advantages and disadvantages of different drug delivery systems; - analyze interactions between polymers and biological environments; - interpret data from experiments focused on controlled drug release and carrier degradation. 4. Communication and teamwork skills The student will be able to: - - Present the results of laboratory and theoretical tasks clearly and comprehensibly; - - Discuss DDS concepts and drug release mechanisms in a group; - - Collaborate in solving practical problems in the laboratory and in designing experiments.
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Prerequisites
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1. Fundamentals of Chemistry - general and physical chemistry (concentrations, equilibria, pH, reaction kinetics) - basics of organic chemistry (functional groups, structure and properties of organic compounds) - fundamentals of polymer chemistry (polymerization, polymer structure, molecular weight, amorphous/crystalline phase) 2. Fundamentals of Physics - basics of transport phenomena (diffusion, flux, concentration gradient) - basic knowledge of Fick's laws is an advantage - fundamentals of materials engineering (mechanical properties, material degradation) 3. Fundamentals of Biology - cell biology (cell structure and function) - basics of human physiology - fundamental principles of biochemistry (enzymes, biomolecular interactions) 4. Mathematical Foundations - basic work with differential equations - logarithmic and exponential functions - basic statistics (evaluation of experimental data)
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Assessment methods and criteria
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Oral exam, Written assignment
Credit: 100% attendance at laboratory exercises and completion of reports, Examination: combined form (written test + oral examination)
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Recommended literature
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BRUSCHI, Marcos Luciano. Strategies to Modify the Drug Release from Pharmaceutical Systems. Cambridge. 2015.
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HEIN L. et. al. Color Atlas of Pharmacology. Thieme Georg: New York. Fifth edition, 2017. ISBN 9783132410657.
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Saltzman, W. M. Drug Delivery ? Engineering Principles for Drug Therapy. New York, 2001. ISBN 0195085892.
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SIEPMANN J. SIEGEL R. A. RATHBONE M. J. Fundamental and Applications of Controlled Release Drug Delivery. Springer, 2012. ISBN 978-1-4614-0881-9.
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