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Lecturer(s)
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Lukáš David, prof. RNDr. CSc.
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Havlíčková Kristýna, Ing.
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Course content
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Lectures: 1. Introduction to drug release systems. 2. Overview of mechanisms of drug release systems. 3. Distribution of controlled release materials, overview of polymers. 4. Diffusion-controlled systems - Random walk. 5. First and second Fick's law. 6. Solution of diffusion equation in Cartesian and cylindrical coordinates. 7. Mathematical model - Higuchi approximation. 8. Porous systems - basics of percolation theory. 9. Diffusion in biological systems, polymers and gels. 10. Passage of drugs through biological barriers. 11. Hydrogels - release systems. 12. Degradable systems, mechanisms of degradation associated with drug release. 13. Basics of pharmacokinetics. 14. Examples of application of release systems. Exercises: The lectures will be practiced at seminars.
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Learning activities and teaching methods
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Project teaching, Problematic methods (research and exploration), Lecture
- Home preparation for classes
- 10 hours per semester
- Preparation for exam
- 60 hours per semester
- Class attendance
- 56 hours per semester
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Learning outcomes
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Synthetic materials have unprecedented potential for the treatment of human diseases. The course is focused on properties and development of biomaterials in relation to polymer chemistry and polymer physics. The aim is a qualitative and quantitative description of the mechanisms and principles that govern the rate of transport and release of drugs, their reactions and their degradation. The aim of the course is to provide basic knowledge for the development of methods and biomaterials for drug delivery and release.
Theoretical knowledge and practical skills in the field.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Combined examination
Attendance at seminars, written and oral exam.
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Recommended literature
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SALTZMAN W. M. Drug Delivery - Engineering Principles for Drug Therapy. Oxford University Press, 2001. ISBN 0195085892.
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SIEPMANN J. SIEGEL R. A. RATHBONE M. J. Fundamental and Applications of Controlled Release Drug Delivery. Springer, 2012. ISBN 978-1-4614-0881-9.
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