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Lecturer(s)
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Klíčová Markéta, Ing. Ph.D.
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Course content
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Lectures 1. Introduction to tissue engineering 2. Structure and function of the cell, description of individual organelles 3. Cell interactions 4. Scaffolds ? vascular nanofibrous substitutes 5. Scaffolds - skin scaffolds, scaffolds for bone tissue engineering, anti-adhesive materials 6. Scaffolds - interaction with the cell 7. Cultivation of cells in vitro 8. Dynamic cell cultivation in vitro 9. Sterilization methods 10. Ethics of tissue engineering 11. Special methods of manufacturing materials 12. Special applications of biomaterials ? microneedles, microfluidic chips Exercises 1. Exercise 1: Work safety, biological laboratory and pipetting 2. Exercise 2: Cells and their passaging 3. Exercise 3: Assessment of cytotoxicity 4. Exercise 4: Testing cell proliferation and adhesion with materials 5. Exercise 5: Materials testing I 6. Exercise 6: Testing materials II
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Learning activities and teaching methods
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Monological explanation (lecture, presentation,briefing), Self-study (text study, reading, problematic tasks, practical tasks, experiments, research, written assignments), Laboratory work, Individual consultation, E-learning
- Class attendance
- 56 hours per semester
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Learning outcomes
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The subject Materials for tissue engineering, taught in the follow-up master's degree, is loosely connected to the subject Fibrous materials for tissue engineering (MAT), Fundamentals of cell and tissue biology (ZBT) and Medical textiles (ZDT). In the introduction, students will get acquainted with the terms used in the field of tissue engineering. Subsequently, interactions between cells and materials and the possibilities of their evaluation in laboratory conditions or directly in living organisms will be discussed. Legal standards for the approval of medical devices and modern therapy products will also be mentioned. In the end, selected applications of tissue engineering and the possibilities of using biomaterials in these applications will be discussed.
Student acquire knowledges of subject.
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Prerequisites
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Unspecified
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Assessment methods and criteria
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Oral exam, Written exam
Credit: Participation on seminars Exam: oral
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Recommended literature
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Alberts B, et al. Základy buněčné biologie, Espero publishing, Ústí nad Labem, 1998.
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Freshney I. R. Culture of Animal Cells, John Wiley & Sons, Inc., 2010. ISBN 978-0-470-52812-9.
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Gary E. Encyclopedia of Biomaterials and Biomedical Engineering, Marcel Dekker, New York, 2004.
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Lanza R.P., Langer R., Vacanti J. Principles of tissue engineering, Second edition, Academic Press, 1997.
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Peter X. Ma. Scaffolds in Tissue Engineering, Taylor and Francis, New York, 2006.
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RATNER, Buddy. Biomaterials Science. 3rd Edition.. Academic Press,, 2013. ISBN 978-0-12-374626-9.
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